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Charcot-Marie-Tooth disorders pathophysiology, molecular genetics, and therapy by International Conference on Charcot-Marie-Tooth Disease (2nd 1987 Harriman, N.Y.)

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Published by Liss in New York .
Written in English


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Book details:

Edition Notes

Statementeditors, Robert E. Lovelace, Howard K. Shapiro.
SeriesNeurology and Neurobiology -- v. 53., Neurology and neurobiology -- v. 53.
ContributionsLovelace, Robert E., Shapiro, Howard K.
LC ClassificationsRC935.C43 I58 1987
The Physical Object
Paginationxxvii, 448 p. :
Number of Pages448
ID Numbers
Open LibraryOL18954353M
ISBN 100845127578, 0471562343
LC Control Number89012889

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This volume discusses developments in research and clinical aspects of Charcot-Marie-Tooth disease (CMT), the most common peripheral neuropathy in humans. The genetic causes of most of the demyelinating forms of CMT have now been identified, and the molecular biology of peripheral nervous structure and the function of many of the molecules involved in the . Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot–Marie–Tooth disorder type 2) and mouse. Am J Hum Genet ; –Author: Odile Dubourg, Alexis Brice, Eric LeGuern.   Charcot-Marie-Tooth, or CMT, is the most common inherited neurological disorder, affecting approximately , Americans. CMT is found world-wide, in all races and ethnic groups. Although discovered in by three physicians, Jean-Marie Charcot, Pierre Marie and Howard Henry Tooth, the disorder has remained a mystery to the general public. signs and symptoms is Charcot-Marie-Tooth disease, or CMT, named after the three physicians who first described it late in the 19th century: Jean-Martin Charcot and Pierre Marie, two French neurologists, and British physician Howard Henry Tooth. Symptoms generally begin in child-hood or adolescence, although onset.

  Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2, people in the United States. The disease is named for the three physicians who first identified it in - Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. Charcot-Marie-Tooth Disease affects the nerves outside the spinal cord and brain. People with the condition can have problems with their feet and trouble balancing. Three doctors -- Jean-Martin Charcot, Pierre Marie and Howard Henry Tooth – identified a nerve disease back in Today, a whole group of genetic disorders is named after that trio. Charcot-Marie-Tooth disease (CMT) is named after its three discoverers, who first noted the disease around the turn of the century. It is the most common inherited peripheral neuropathy in the world, characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm and a mild loss of sensation in the limbs, fingers, and toes.   Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, and nearly all cases are inherited. CMT damages the body's peripheral nerves, making them unable to activate muscles or relay sensory informaton from the limbs back to the spinal cord and the brain.

Charcot-Marie-Tooth Disease (CMT) is the most common inherited neurological condition, affecting one in 2, people or , in the United States and million people worldwide. Due to damage to the nerves, it causes progressive weakness and wasting of muscles in the lower arms and legs.   Charcot-Marie-Tooth neuropathy X type 1 (CMTX1) is characterized by a moderate to severe motor and sensory neuropathy in affected males and usually mild to no symptoms in carrier females. Sensorineural deafness and central nervous system symptoms also occur in Cited by: 3.   Aug ; 40 (8) Book Reviews. Charcot‐Marie‐Tooth Disorders Pathophysiology, Molecular Genetics, and Therapy (Neurology and Neurobiology, Vol. 63) (Proceedings of the Second International Conference on Charcot‐Marie‐Tooth Disease, Held at Harriman, NY, June 28‐July 1, ) Author: Hiroshi Mitsumoto.   Charcot-Marie-Tooth disease (CMT) is one of the most frequent inherited neurological disorders, involving about 1 in 2, people in the USA. CMT, also termed hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, consists of a group of disorders that affect peripheral : Kenneth Kee.